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Efavir®

Efavir® is an anti-retroviral drug used alongside other medications of the same class to treat HIV-1 infection in patients of 3 months and older (weighing at least 3,5 kg). Efavir® is not a cure of HIV or AIDS. Efavir® and other anti-HIV drugs are taken in order to control HIV infection and decrease illnesses associated with HIV. Read more

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Description

Efavir® is manufactured by Cipla. The raw material is Efavirenz – a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Indications:

- treating HIV type 1 infection in combination with other anti-retroviral drugs in patients 3 months and older.

Efavirenz is also used in conjunction with other anti-retroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.

For HIV-1 infection that has not previously been treated, Efavirenz and Lamivudine in combination with Zidovudine or Tenofovir is the preferred NNRTI-based regimen.

MOA (mechanism of action):

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with potent antiviral activity. Efavirenz binds directly to the HIV-1 RT, an RNA-dependent DNA polymerase, suppressing its function in viral DNA replication. In combination with other anti-retroviral drugs, Efavirenz has been shown to dramatically reduce HIV viral load, halting or preventing damage to the immune system and decreasing the risk of developing AIDS. Efavirenz isn't active against HIV-2.

Dosage

For adults and children 12 years of age and older: 300 mg tablet each day.

For adults with kidney problems, Efavir® may be taken less often.

Adults and children 12 years of age and older who cannot swallow Efavir® tablets are usually prescribed Efavirenz oral powder.

For children 2-12 years of age, the right dose of Efavirenz oral powder or tablets based on the child’s body weight will be prescribed.

Tell the doctor if the child has problems with swallowing tablets.

Precautions:

HIV can be transmitted through sexual contact with HIV positive partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes).Therefore, both HIV-positive and HIV-negative individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Some people who take Efavir® may experience:

- Serious mental health problems (depression, anxiety, restlessness, having thoughts of suicide, hallucination etc.). If you have any of these symptoms, seek emergency medical attention immediately.

- Nervous system symptoms are common and can be severe during taking Efavir® (dizziness, trouble sleeping, trouble concentrating, drowsiness, and unusual dreams). If you feel dizzy, cannot concentrate or feel drowsiness, do not drive, operate machinery.

- Skin rash is common with Efavir® but can be severe. The rash usually goes away without change in treatment. Tell your doctor right away if you have symptoms: skin rash with or without itching, fever, swelling of your face, blisters or skin lesions, exfoliating skin, mouth sores, red or inflamed eyes.

- Liver problems, including liver failure and death. If you have liver problems, do blood tests to check your liver before you start Efavir® and during treatment. Liver problems can happen in people without a history of liver problems. Tell your doctor immediately if you have symptoms: jaundice, dark colored urine, light colored stools, nausea, abdominal pain.

- Seizures, changes in your immune system, changes in body fat.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Efavir® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Efavir® tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Efavir® in the original container. Do not use Efavir® if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

Common and uncommon side effects associated with Efavir® are:

  • rash
  • dizziness
  • nausea
  • headache
  • difficulty concentrating
  • abnormal dreams
  • tiredness
  • trouble sleeping
  • vomiting

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Efavir® is contraindicated in patients who are allergic to Efavirenz or any of the other ingredients of Efavir®.

Do not take Efavir® in patients younger than 3 months (weight under 3,5 kg).

Do not take Efavir® if you have heart condition, have ever had mental illness or used street drugs, consume a lot of alcohol, liver problems including hepatitis, history of seizures.

Do not take Efavir® if you are pregnant or plan to become pregnant.

Women should not become pregnant and should use two effective birth control methods while taking Efavir® and for 12 weeks after stopping it. A barrier form of contraception like condom, contraceptive sponge, diaphragm, cervical cap should always be used along with another method of contraception.

Hormonal contraceptives like pills, injections, vaginal rings, or implants may not work during treatment with Efavir®.

Do not take Efavir® if you take Atripla (Efavirenz/Emtricitabine/ Tenofovir Disoproxil Fumarate) unless your doctor tells you to.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Do not take Efavir® if you are pregnant or plan to have a baby. First, consult your healthcare provider.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Q: What is Efavir® used for?

A: Efavir® is an anti-retroviral drug used alongside other medications of the same class to treat HIV-1 infection in patients of 3 months and older (weighing at least 3,5 kg). Efavir® is not a cure of HIV or AIDS. Efavir® and other anti-HIV drugs are taken in order to control HIV infection and decrease illnesses associated with HIV.

Q: Can I have sex when taking Efavir®?

A: You should know neither Efavir® nor any other anti-retroviral medication can cure HIV. It is therefore important that you have safe sex and take other precautions to avoid passing HIV on to other people. Do not have any kind of sex without using a latex or polyurethane condom.

Q: Can I breastfeed if I take Efavir®?

A: Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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