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Atripla

Atripla is a potent combination anti-retroviral drug. Atripla contains three main components, allowing to show a high efficacy in the treatment of HIV-1 infection in treatment-experienced patients. Atripla is not a cure of HIV-1 and AIDS.

Other names for this medication:
Viraday®

Similar Products:
Abamune-L®, Epzicom, Duovir®®, Synthivan®, Virataz R, Lopimune®, Kaletra, Trioday®, Avonza, Triomune®, Emtri, Duovir-N®, Truvada, Tenof EM®, Tofocom®, Tentide EM®, Ricovir EM®, Tenvir®, Tenvir-EM®, Atripla, Viread, Lamivir®, Combivir®, Abamune L®, Abalam®, A Bec L®, Abamune®, A Bec®, Virol®, Ziagen, Zidovir®, Efavir®, Stocrin, Nevimune®, Viramune, Atazor®, Reyataz, Daruvir®, Prezista, Ritomune®, Norvir, Isentress®, Zepdon®

Active Ingredient:
Tenofovir Disoproxil, Emtricitabine, Efavirenz

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USD 302.40 per bottle   -20% USD 378.00 USD 302.40 per bottle   Order now
2 bottles

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3 bottles

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USD 294.84 per bottle   -20% USD 1105.65 USD 884.52 per 3 bottles   Order now

Save USD 22.68

Description

Atripla comprises three active compounds – Emtricitabine, a nucleoside reverse transcriptase (RT) inhibitor, Tenofovir is a nucleotide reverse transcriptase inhibitor, and Efavirenz, a non-nucleoside reverse transcriptase inhibitor.

Indications:

-human immunodeficiency virus type 1 (HIV-1) infection in adults 18 years of age and older who have been treated with other anti-retrovirals and have their HIV-1 infection under control for at least 3 months.

Note, that patients who want to start Atripla therapy must not have experienced failure of a previous HIV therapy.

MOA (mechanism of action):

Tenofovir (TDF) and Emtricitabine (FTC) are known as NRTIs and they work by interfering with the normal working of an enzyme reverse transcriptase that is crucial for the HIV to reproduce itself. Efavirenz (EFV) binds directly to the HIV-1 RT, an RNA-dependent DNA polymerase, suppressing its function in viral DNA replication. Therefore, Atripla reduces the viral load in blood, increases the count of CD4 (T) cells in blood which aids in warding off other infections. Tenofovir, Emtricitabine, Efavirenz are not active against HIV-2.

Dosage

The usual dose of Atripla is one tablet once a day, at the same time.

Take Atripla on an empty stomach (2 hours after food) at bedtime. Bedtime dosing helps reduce the impact of some of the side effects, especially during the first few weeks.

Do not run out of Atripla. Refill the prescription or talk to your doctor before Atripla is gone.

Precautions:

HIV can be transmitted through sexual contact with infected partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both infected and non-infected individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors.

It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Some people who take Atripla may experience:

Nervous system symptoms are common and can be severe (dizziness, trouble sleeping, trouble concentrating, drowsiness, and unusual dreams). If you feel dizzy, cannot concentrate or feel drowsiness, do not drive, operate machinery. These side effects may start in the first 1 or 2 days of treatment and usually go away after the first 2 to 4 weeks.

Serious liver problems: hepatomegaly, steatosis. The symptoms of liver problems: jaundice, dark “tea-colored” urine, light-colored bowel movements, loss of appetite for several days or longer, nausea. If you experience these symptoms, seek emergency medical attention immediately.

Skin rash is common but can be severe. If you see any signs of a severe rash with blistering or fever, stop taking Atripla and tell your doctor at once. If you had a rash while taking another NNRTI, you may be at higher risk of getting a rash with Atripla.

Immune Reconstitution Syndrome – a condition when immune system may get stronger and starts fighting infections that have been hidden in the body for a long time.

Osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).

Missing a dose

If you notice a missing within 12 hours of the time you usually take Atripla, you must take the tablet as soon as possible. Then take the next dose as usual. If you notice 12 hours or more after the time you usually take Atripla, then do not take the missed dose. Wait and take the next dose at your usual time. Do not take a double dose of Atripla to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Atripla tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Atripla in the original container. Do not use Atripla if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common and uncommon side effects associated with Atripla are:

  • dizziness/light headiness, headache, insomnia, vivid (real-feeling) dreams
  • feeling worried, depressed or angry
  • nausea, vomiting, diarrhoea
  • rash, weakness, tiredness

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Atripla is contraindicated in patients who are allergic to Emtricitabine, Tenofovir, Efavirenz or any of the other ingredients of Atripla.

Do not use Atripla in patients under 18 years of age and in patients over 65 years of age.

Do not let your Atripla run out. Refill your tablets if therapy is continued.

Do not stop taking Atripla suddenly and without first talking to the doctor.

Do not take Atripla if you have liver problems, including HBV infection, kidney problems, bone problems, a history of mental illness (depression, alcohol abuse), a history of convulsions (fits or seizures).

Do not take Atripla if you are pregnant or plan to have baby, are breastfeeding or plan to breastfeed.

Do not combine Atripla with other medicines that contain Tenofovir (Complera®, Stribildtm, Truvada), adefovir (Hepsera®), didanosine (Videx, Videx EC), atazanavir (Reyataz), lopinavir with ritonavir (Kaletra), darunavir (Prezista), ledipasvir with sofosbuvir (Harvoni®), sofosbuvir with velpatasvir (Epclusa®), astemizole or terfenadine, bepridil, cisapride, ergot alkaloids, midazolam or triazolam, pimozide, voriconazole, acyclovir, adefovir dipivoxil, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), anticonvulsants (carbamazepine, phenytoin, phenobarbital), immunosuppressants, anticoagulants, antidepressants (Sertraline), antifungals (itraconazole or posaconazole), methadone (to treat opiate addiction), high-dose or multiple NSAIDs, products containing St John’s wort, calcium or iron supplements, multivitamins.

Women should not become pregnant and should use two effective birth control methods while taking Atripla and for 12 weeks after stopping it. A barrier form of contraception like condom, contraceptive sponge, diaphragm, cervical cap should always be used along with another method of contraception.

Hormonal contraceptives like pills, injections, vaginal rings, or implants may not work during treatment with Atripla.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Consult your doctor before taking Atripla if you are pregnant or plan to have a baby.

Alcoholism, hepatic disease, hepatotoxicity or lactic acidosis, obesity, organ transplantation are contraindications for using Atripla.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Q: What is Atripla used for?

A: Atripla is a potent combination anti-retroviral drug. Atripla contains three main components, allowing to show a high efficacy in the treatment of HIV-1 infection in treatment-experienced patients. Atripla is not a cure of HIV-1 and AIDS.

Q: Can I have sex when taking Atripla?

A: You should know neither Atripla nor any other anti-retroviral medication can cure HIV. It is therefore important that you have safe sex and take other precautions to avoid passing HIV on to other people. Do not have any kind of sex without using a latex or polyurethane condom.

Q: Is Atripla safe during pregnancy?

A: Consult your doctor before taking Atripla if you are pregnant or plan to have a baby.

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