Description
Ciprodex ophthalmic and otic solution contains two active ingredients Ciprofloxacin (second-generation Fluoroquinolone antibiotic) and Dexamethasone (synthetic member of the glucocorticoid class of steroid hormones), which allows to reduce itchiness, swelling or reddening while fighting and eliminating the infection.
Indications:
- bacterial eye infections (conjunctivitis, corneal ulcers, superficial infections of the eye and adnexa);
- bacterial ear infections (otitis externa, acute otitis media, chronic suppurative otitis media);
- alleviating infection symptoms such as irritation, itchiness, swelling or reddening;
- prophylaxis in otic surgeries such as mastoid surgery.
MOA (mechanism of action):
Ciprofloxacin is a synthetic antimicrobial agent that exhibits its bactericidal action through inhibiting the bacterial DNA gyrase enzyme, required for bacterial DNA replication, transcription, repair and recombination. Dexamethasone is a potent corticosteroid that effectively controls the inflammation by inhibiting the release inflammatory mediators. Namely, it involves phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Ciprofloxacin is effective against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, Staphylococcus epidermidis and Streptococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes, Campylobacter jejuni, Shigella flexneri and Shigella sonnei.
Dosage
For corneal ulcers: instill 2 drops into the treated eye every 15 minutes for the first 6 hours and then 2 drops into the treated eye every 30 minutes for the remainder of day 1.
Day 2: instill 2 drops in the treated eye hourly.
Day 3 - Day 14: instill 2 drops in the treated eye every 4 hours.
Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.
For conjunctivitis: instill 1 or 2 drops instilled into the conjunctival sac(s) every 2 hours, while awake, for 2 days and 1 or 2 drops every 4 hours, while awake, for the next 5 days.
For superficial eye infection: instill 1 or 2 drops in the treated eye(s) 4 times a day. In severe infections, the dosage for the first 2 days may be 1 or 2 drops every 2 hours while awake.
The maximum duration of therapy of 21 days is recommended.
For ear infections: instill 2-3 drops every 2-3 hours initially, reducing the frequency of the instillation with control of infection.
Precautions:
Ciprodex ophthalmic and otic solution is associated with allergic reactions, even following a single dose. Discontinue using drops immediately and contact your physician at the first sign of a rash or allergic reaction.
Prolonged use of Ciprodex ophthalmic and otic solution may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue using these drops and institute alternative therapy.
Ciprodex ophthalmic and otic solution may cause your vision to blur temporarily after you have applied them into your eye. Do not drive or operate machinery until this has worn off.
Avoid contaminating the applicator tip with eye, fingers or another source.
Patients should not wear contact lenses while using Ciprodex ophthalmic and otic solution for eye infection.
Wash your hands before using the eye and ear drops.
Missing a dose
If you miss a dose you should instill it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.
Overdose
If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately. A topical overdose of Ciprodex ophthalmic and otic solution may be flushed from the eye(s) with lukewarm tap water.
Storage
Store at cool room temperature not exceeding 30 C degrees, away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. Use within one month after opening a container. Keep out of the reach of children.
