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Hydrocl®

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Hydrocl®

Hydrocl® is a diuretic and antihypertensive medicine indicated to treat high blood pressure and reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver or kidney disease. Hydrocl® is also beneficial for the management of nephrogenic diabetes insipidus and treatment of osteoporosis. The medication is suitable for use in patients of all ages. Read more

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Description

The medication is manufactured by Digital Vision Pharma and marketed by Johnlee Pharmaceuticals Pvt. Ltd. Hydrocl® belongs to a class of drugs known as thiazide diuretics and contains the active ingredient Hydrochlorothiazide that works by causing the kidneys to remove excess salt and water which decreases the risk of fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used for the management of nephrogenic diabetes insipidus, caused by the inability of kidneys to respond to antidiuretic hormone (ADH). Hydrocl® helps treat high blood pressure (hypertension), lowering the risks of strokes, heart attacks, and kidney problems.

Indications:

- management of hypertension (either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension);

- fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen;

- alternative oral agent for management of nephrogenic diabetes insipidus (should not be confused with diabetes mellitus or sugar diabetes), followed by abnormal production of urine (polyuria) and constant thirst (polydipsia);

- treatment of osteoporosis (an increased bone weakness that may lead to a broken bone).

MOA (mechanism of action):

The active substance Hydrochlorothiazide works by causing the kidneys to remove extra water and salt from the blood and pass it out through the urine. By increasing the amount of water removed from the blood, the medicine promotes the reduction in blood volume, thus lowering blood pressure. By getting rid of unneeded water from the body, Hydrochlorothiazide helps diminish swelling and water retention. Hydrocl® reduces polyuria in patients with diabetes insipidus, thereby diminishing water delivery to the ADH-sensitive sites in the collecting tubules and increasing urine osmolarity. Hydrochlorothiazide, like other thiazides, tends to increase the reabsorption of calcium, decreasing mineral bone loss and promoting differentiation of osteoblasts, which is beneficial for the osteoporosis treatment.

Dosage

For high blood pressure:

- Adults (ages 18 - 64 years) - the starting dosage is 25 mg taken by mouth once per day. Your doctor may increase your dosage to 50 mg per day if your blood pressure stays high.

- Children (ages 12 - 17 years) - the starting dosage is 25 mg taken by mouth once per day. Your doctor may increase the dosage to 50 mg per day if your child’s blood pressure stays high.

- Children (ages 3 - 11 years) - the usual dosage is 0.5 to1 mg per pound (1 to 2 mg/kg) a day, taken in a single dose or two divided doses. The dosage per day should not exceed 100 mg.

- Children (ages 6 months - 2 years) - the usual dosage is 0.5 to 1 mg per pound (1 to 2 mg/kg) per day, taken in a single dose or two divided doses. The dosage per day should not be more than 37.5 mg.

- Children (ages 0 - 6 months) - the usual dosage is up to 1.5 mg per pound (up to 3 mg/kg) per day, taken in two divided doses.

- Seniors (ages 65 years and older) - the dosage should be individualized according to patient response.

Hydrocl® oral administration in children who are not able to swallow a tablet can be done in the form of suspension in the concentration of 5mg/ml.

For edema:

- Adults (ages 18 - 64 years) - the usual dosage is 25 - 100 mg each day, taken by mouth as a single or divided dose. May be used intermittently (every other day or 3 – 5 days each week) if advised by your doctor.

- Children (ages 12 - 17 years) - the usual dosage is 25 - 100 mg each day, taken by mouth as a single or divided dose. May be used intermittently (every other day or 3 – 5 days each week) if advised by your child’s pediatrician.

- Children (ages 3 - 11 years) - the usual dosage is 0.5 to 1 mg per pound (1 to 2 mg/kg) per day, taken in a single dose or two divided doses. The dosage per day should not exceed100 mg.

- Children (ages 6 months - 2 years) - the usual dosage is 0.5 to 1 mg per pound (1 to 2 mg/kg) per day, taken in a single dose or two divided doses. The dosage per day should not be more than 37.5 mg.

- Children (ages 0 - 6 months) - the usual dosage is up to 1.5 mg per pound (up to 3 mg/kg) per day in two divided doses.

- Senior dosage (ages 65 years and older) – the dosage should be individualized according to patient response.

Hydrocl® oral administration in children who are not able to swallow a tablet can be done in the form of suspension in the concentration of 5mg/ml.

For diabetes insipidus:

- Adults - the initial dose is 50 mg orally once a day, which may be increased to 10mg per day for maintenance.

- Children - the dosage should be advised by a pediatrician.

For osteoporosis:

- Initial dose: 25 mg orally once daily.

- Maintenance dose may be increased up to 50 mg a day.

Missing a dose

If you miss a dose of Hydrocl® you should take it as soon as possible. If it is the time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not exceed the doctor’s recommended dose.

Overdose

If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately. Do not exceed the doctor’s recommended dose.

Storage

Store at a room temperature between 20° to 25°C (68° to 77°F) away from excess moisture and heat. Keep Hydrocl® in the original container and throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Hydrocl® are:

  • - thirst
  • - weakness
  • - dizziness
  • - headache
  • - confusion
  • - nausea or vomiting
  • - seizures
  • - muscle pain or cramps
  • - muscle fatigue
  • - lower than normal blood pressure
  • - higher than normal heart rate
  • - producing less urine than normal
  • - tingling in your hands, legs, and feet

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Hydrocl® if you are allergic to Hydrochlorothiazide or any other sulfonamide-derived drug.

Avoid drinking alcohol while taking Hydrocl® as it may significantly lower your blood pressure.

Use Hydrocl® with caution if you have a poor liver function or progressive liver disease.

Do not use the medication if your kidneys cannot make enough urine.

Do not take the tablets if you have recently had a sympathectomy (surgical removal of at least one ganglia of the sympathetic nervous system).

Do not use the medicine if you have hypercalcemia, hypochloremia, hyperuricemia, hypokalemia, hyponatremia, hypomagnesemia, pancreatitis, asthma anuria, diabetes, gout, hepatic coma or pre-coma, or systemic lupus erythematosus.

Do not take this medication concurrently with vitamin D or its analogs, nausea drugs (dolasetron), anti-inflammatory medicines (naproxen, aspirin, diclofenac, ibuprofen, naproxen), muscle relaxants (diazepam, clonazepam, lorazepam), barbiturates for sleep or seizure control (pentobarbital, secobarbital, mephobarbital, pentobarbital), heart medications (digoxin, dofetilide), antipsychotic drugs (haloperidol, lithium), antidiabetics (chlorpropamide), amphetamines (lisdexamfetamine), high blood pressure medications (enalapril, perindopril, irbesartan), muscle relaxants (diazepam, lorazepam, clonazepam), other diuretics or anticoagulants (warfarin).

Do not take the Hydrocl® tablets if you are pregnant or breastfeeding without consulting your doctor.

Q: What is Hydrocl® used for?

A: Hydrocl® is a diuretic and antihypertensive used in the treatment of edema associated with certain health conditions, like heart failure or renal dysfunction among others, and management elevated blood pressure (hypertension).

Q: What should I know while taking the medicine?

A: You can take Hydrocl® with or without food. Take this drug preferably in the morning, not the evening. As this medication may make you urinate more, taking it in the evening can make you need to get up at night to use the bathroom.

Q: Is Hydrocl® safe for women who are pregnant or breastfeeding?

A: This drug should only be used in pregnant women if clearly needed. Hydrocl® is not recommended during lactation period as the medicine may pass into breast milk and cause side effects in a child who is breastfed. Talk to your doctor before taking this medication.

Q: Can Hydrocl® be used in senior patients?

A: Yes, but the dose should be individualized for each patient. Since older adults may process drugs more slowly, a normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule, as advised by your doctor.

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Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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