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Minirin®

Minirin® is an oral antidiuretic medication used to decrease the overproduction of urine associated with primary nocturnal enuresis (bed-wetting), post-hypophysectomy polyuria, and diabetes insipidus. These tablets aid in maintaining the water balance in the body. Suitable for individuals from 6 to 65 years of age.

Other names for this medication:
DDAVP, DDAVP Melt, Desmopressin Tablets, Nocdurna, PMS-desmopressin, Teva-desmopressin, Apo-desmopressin

Similar Products:
Minirin® Nasal Spray, DDAVP Spray, Nu-desmopressin Spray, Octostim Spray, Stimate, Desmopressin Acetate Solution, Dpressin Nasal Spray, Cpressin-P® Injection, Pitressin®, Vasostrict®, Vasopar, Vasmed, Press Up

Active Ingredient:
Desmopressin Acetate

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Description

Minirin® is manufactured by Ferring Pharmaceuticals. It is antidiuretic treatment used to increase urine concentration and promote kidney ability to conserve water. The active ingredient of Minirin® tablets is Desmopressin, a synthetic substitute for antidiuretic hormone (also known as vasopressin or ADH) human body produces naturally.

Indications:

Minirin® tablets help relieve the symptoms of the following diseases:

- cranial diabetes insipidus, followed by abnormal production of urine (polyuria) and constant thirst (polydipsia). Do not confuse with diabetes mellitus (sugar diabetes).

- primary nocturnal enuresis (bed-wetting) in patients who are able to concentrate urine normally and have not responded to safer treatments (alarms);

- post-hypophysectomy polyuria/polydipsia.

A single dose of Minirin® can also be used as a diagnostic test to establish if the kidneys are able to concentrate urine.

Although Minirin® aids in decreasing urine overproduction, it does not cure the cause of the aforementioned conditions.

MOA (mechanism of action):

Desmopressin is a potent vasopressin receptor 2 (V2 receptor) modulating the mechanism of water homeostasis maintenance and urine concentration. In particular, Desmopressin promotes water permeability in renal tubular cells, therefore inhibits the abnormal production of urine and increases its concentration. Also, Desmopressin has vasoconstricting properties.

Dosage

Minirin® tablets should be swallowed whole and taken with a few sips of water.

Primary nocturnal enuresis (bed-wetting):

Start with taking 0,2 mg daily at bedtime. After 4 weeks, your doctor will adjust the dose to the most suitable for you. The usual recommended dose may vary from 0,2 to 0,4 mg daily. The usual course duration is up to 3 months.

If after 4 weeks of treatment with Minirin® your nocturnal enuresis has not improved, stop taking the pills and seek medical advice.

Avoid drinking fluids 1 hour before and 8 hours after taking Minirin®. You can drink no more than a few sips of water during this period.

Central diabetes insipidus:

The dosage, as well as the course duration, must be determined by a doctor for each individual patient.

The recommended starting dose is 0,05 mg every 12 hours.

For adults and children over 12 years the daily dose usually varies from 0,1 to 1,2 mg daily every 8-12 hours.

For children of 6 to under 12 years the daily dose usually varies from 0,1 to 0,8 mg daily every 8-12 hours.

Precautions:

Minirin® tablets are only for oral use.

Avoid excessive fluid intake during the Minirin® treatment course as this may lead to a build-up of water in your body.

Do not stop taking Minirin® or lower the dosage unless your doctor has instructed you too.

Avoid using Minirin® if you are older than 65 years of age.

Do not give Minirin® to children under 6 years of age.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is time for the next dose you should continue your regular dosing schedule. Do not take a double dose.

Overdose

Do not exceed the doctor's recommended dose. The symptoms of Minirin® overdose may include confusion, drowsiness, continuing headache, nausea or vomiting, rapid weight gain, and convulsions in severe cases. If any of these occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a room temperature from 20 to 25 degrees C (68 to 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

Side effects

The most common side effects associated with the use of Minirin® are:

  • behavioral and visual disturbances
  • nervousness
  • bladder problems
  • fatigue
  • headache
  • stomach pain or nausea
  • allergic reactions (difficulty breathing, rash, itching, swelling on the face, lips, tongue)

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Minirin® if you are allergic to Desmopressin or antidiuretic hormone (vasopressin).

Do not take Minirin® if you are allergic to any of the other ingredients comprised in Minirin®.

Do not combine Minirin® with the use of diuretics.

Do not take Minirin® if you have anuria, heart or blood vessel disease, low blood pressure, cystic fibrosis, syndrome of inappropriate antidiuretic hormone secretion (SIADH), polydipsia, psychogenic polydipsia, cardiac insufficiency, or any medical condition causing fluid and/or electrolyte imbalance or any disease of the blood clotting cells (platelets).

Do not use Minirin® if you are taking diarrhoea drugs (loperamide), tricyclic antidepressants (clomipramine, imipramine, desipramine), SSRIs (citalopram, paroxetine, sertraline), antipsychotics (chlorpromazine), epilepsy drugs (carbamazepine), antidiabetics (chlorpropamide), high blood pressure medications (enalapril, perindopril, irbesartan), and non-steroidal anti-inflammatory drugs (aspirin and ibuprofen).

Do not take Minirin® if you have low levels of sodium in your blood.

Do not use Minirin® in patients under 6 years of age.

It is recommended not to use Minirin® in patients over 65 years of age.

It is recommended not to use Minirin® in pregnant women unless considered absolutely necessary by your doctor.

It is strictly prohibited to breastfeed during the Minirin® treatment course.

Q: What is Minirin®?

A: Minirin® is an oral antidiuretic medication used to decrease the overproduction of urine associated with primary nocturnal enuresis (bed-wetting) and diabetes insipidus. These tablets aid in maintaining the water balance in the body.

Q: Can Minirin® be used in pregnant women?

A: It is recommended not to use Minirin® in pregnant women unless considered absolutely necessary by your doctor.

Q: Is Minirin® suitable for elderly people?

A: It is recommended not to use Minirin® in patients over 65 years of age.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

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Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
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