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About ZO® Eye and Ear Drops

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ZO® Eye and Ear Drops are manufactured by FDC. The active ingredient of the medication is Ofloxacin, second-generation antibiotic from the Quinolones class, also known as Fluoroquinolones.


- bacterial eye infections (conjunctivitis, mucopurulent conjunctivitis, blepharoconjunctivitis, and blepharitis);

- bacterial ear infections (otitis externa, chronic suppurative otitis media with perforated tympanic membranes and acute otitis media in the presence of tympanostomy tubes).

Ofloxacin has been shown to be active against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Propionibacterium acnes, Enterobacter cloacae, Haemophilus influenzae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens.

Do not use ZO® Eye and Ear Drops to treat a viral or fungal infection in the eye or ear.

MOA (mechanism of action):

Ofloxacin is a broad-spectrum antibiotic, active against both gram-positive and gram-negative bacteria. It inhibits DNA gyrase (type II topoisomerase, and topoisomerase IV) – an enzyme crucial for separating replicated DNA. This interferes with normal bacterial cell division and results in bacteria death and elimination of the infection as well.


For bacterial eye infections:

Conjunctivitis: during days 1-2 instill 1 to 2 drops every two to four hours in the treated eye(s) during first two days; during days 3-7 instill 1 to 2 drops four times daily.

Corneal ulcer: instill 1 to 2 drops in the treated eye(s) every 30 minutes, while awake (awaken at four and six hours after sleeping and instill 1 to 2 drops); during days 3-7 to 9 instill 1 to 2 drops hourly, while awake; during days 7 to 9 instill 1 to 2 drops, four times daily.

In severe infections, apply 2 drops into the treated eye(s) hourly until improvement is obtained following which treatment should be reduced.

For ear infections:

Otitis externa: 10 drops twice daily.

Suppurative otitis media with perforated tympanic membranes: 10 drops twice daily for 14 days.


Ofloxacin solution is not for injection.

Ofloxacin solution is associated with allergic reactions, even following a single dose. Discontinue using drops immediately and contact your physician at the first sign of a rash or allergic reaction.

Prolonged use may result in a fungal infection. If superinfection occurs discontinue use and institute alternative therapy.

ZO® Eye and Ear Drops may cause your vision to blur temporarily after you have applied them into your eye. Do not drive or operate machinery until this has worn off.

Avoid contaminating the applicator tip with eye, fingers or another source.

Remove contact lenses before using Ofloxacin drops for eye infection.

Wash your hands before using the eye drops.

Missing a dose

If you miss a dose you should instill it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.


If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.


Store at cool room temperature, away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. Use within one month after opening a container. Keep out of the reach of children.

Side effects

The most common side effects associated with ZO® Eye and Ear Drops are:

  • If applied to eyes:
  • pruritus
  • earache
  • dizziness
  • headache
  • vertigo
  • nausea
  • seborrhea
  • If applied to ears:
  • loss of hearing
  • tinnitus
  • tremor
  • fungal infection
  • dermatitis
  • eczema
  • erythematous rash
  • follicular rash
  • hypoaesthesia
  • hot flushes
  • otorrhagia

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.


Do not use ZO® Eye and Ear Drops if you are allergic to Ofloxacin or other quinolones, or to any of the ingredients in this medication.

Patients should not wear contact lenses while using ZO® Eye and Ear Drops for eye infection.

Do not use ZO® Eye and Ear Drops if you have ever had severe allergic reactions associated with using antibiotics.

Do not use ZO® Eye and Ear Drops in combination with products or medications containing caffeine, anticoagulants (warfarin), cyclosporines.

Do not use ZO® Eye and Ear Drops during pregnancy until considered absolutely necessary by your physician.

Do not use ZO® Eye and Ear Drops in infants below the age of 1 year.

Q: What are ZO® Eye and Ear Drops used for?

A: ZO® Eye and Ear Drops are indicated for the treatment of bacterial infections of eyes and ears in adults and children over 1 year. The indications include corneal ulcers, conjunctivitis, otitis externa, acute otitis media among others. ZO® Eye and Ear Drops are for topical ophthalmic and otic use only. Not for injection.

Q: Are ZO® Eye and Ear Drops safe?

A: ZO® Eye and Ear Drops are safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Q: Are ZO® Eye and Ear Drops safe if used during pregnancy?

A: It is advisable not to use ZO® Eye and Ear Drops during pregnancy until considered absolutely necessary by your physician.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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